Curcuma Phospholipid Complex
Curcumin is the yellow pigment of turmeric Despite evidence in vitro of curcumin’s effectiveness as an anti-inflammatory agent with a wide range of clinical applications, curcumin (and its active curcuminoid components monomolecular curcumin, demethoxycurcumin and bisdemethoxycurcumin) in its raw state is not bioavailable Many supplements in the market have not addressed this issue and are therefore ineffective. The Curcuma Phospholipid Complex used in Turmeric+ and Joint Advanced is a patented form of curcumin that is highly bioavailable.
Without evidence of bioavailability, no supplement can claim to be effective. Our turmeric products are based on the Cucuma Phospholipid Complex formulation which combines curcumin (extracted from turmeric) with soy lecithin, formulated in a 1:2 weight ratio, to overcome two significant problems relating to the bioavailability of curcumin The first issue is that at the small intestine pH of 7-8, curcumin is unstable The half life of curcumin at this pH is less than 7 to 10 minutes (Anand P et alBioavailability of curcumin: problems and promisesMol Pharm 2007; 4:807-1818). The second issue is that curcumin is sparingly soluble in both water and lipophilic compounds, and is very poorly absorbed in the small intestine.
Combining curcumin in a phospholipid such as soy lecithin protects the curcumin from the pH of the intestine (data shows that for Cucuma Phospholipid Complex after 1,000 minutes, 82% is unscathed vs <<1% for curcumin alone) Furthermore, embedded into a lipidic matrix through combination with a phospholipid, it also allows the curcumin to be taken up relatively easily by the biological membranes of the small intestine Overall, this has been shown to improve its bioavailability by a factor of around 30x [Ref JNatProd2011, 74, 664-669].